The One Chicago franchise features characters running into burning buildings, chasing down dangerous criminals, and treating patients in the emergency department of one of the city’s biggest hospitals. So, while some jobs are more perilous than others (looking at you, Chicago Fire), death is all around the characters. They lose people almost every season. Of course, some characters leave the One Chicago universe in one piece, but that doesn’t make their exits hurt any less. No matter how they leave, significant characters departing their respective series will always be upsetting.
10Leslie Shay
Played By Lauren German

Leslie Shay’s tragic death in Chicago Fire season 3 was the One Chicago franchise’s first major loss, and it still stings to this day. During the season 2 finale, almost the entire Firehouse 51 crew (sans Chief Boden) entered a building that seemingly only had a small fire inside. However, an explosion wracked the structure, leaving the audience wondering the fates of several characters. Unfortunately, they had to wait a few months until the season 3 premiere, which revealed that Shay had died in the explosion.